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. 2015 Nov 25;5:17038. doi: 10.1038/srep17038

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Copyright © 2015, Macmillan Publishers Limited

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(A) 2D projection of the top principal component of the H3 nucleosome onto the representative structure, viewed from the side of the DNA pseudo-dyad, highlights mobility in the H2A’ acidic patch restrained by H3′ and a lack of movement in H3′ loop 1. The inset displays the single-unit motion of the H3 dimerization interface. (B) 2D projection of the top principal component onto the representative structure for the CENP-A nucleosome highlights mobility in the H2A’ acidic patch unrestrained by CENP-A’ and enhanced fluctuations in CENP-A’ loop 1. The inset displays the shearing and pinching motion of the CENP-A dimerization interface. Structure figures rendered in VMD.