Figure 2. The computer predicted secondary structure of domain V of the internal ribosome entry site (IRES) in the 5′-UTR region of polioviruses.
(a) Sabin 1 strain; (b) Guizhou/China cVDPV strain; (c) Mahoney strain. The numerals refer to the positions of the nucleotides of Sabin 1. The attenuated determinants sites 480 and 525 in domain V are highlighted in red and sites 476 and 529 in domain V are highlighted in blue.