FIG 1.

Effects of LT-II adjuvants on ricin toxin-specific serum IgG levels when coadministered with two different candidate ricin subunit vaccine antigens. As indicated in Materials and Methods, groups of BALB/c mice (n = 10 per group) were immunized by the i.d. route on days 0, 10, and 20 with high- or low-dose RiVax (A and B) or RVEc (C) with indicated LT-II adjuvants. Sera were collected on day 17 (left panels) or 27 (right panels) and analyzed for ricin-specific serum IgG by ELISA. The dash (-) on the far right of each x axis indicates no adjuvant addition. Seroconversion was defined as an endpoint titer of ≥1:100. Mice that had not seroconverted were arbitrarily assigned a titer of 1 to enable determination of GMT. *, P < 0.05.