FIG 4.

Protective effect of TNF-α vaccine in chronic colitis model. One week after the last immunization, mice were fed by three cycles of administration of 2% DSS in drinking water for 5 days, alternating with 5-day periods of recovery. (A) Photomicrographs of representative H&E-stained colon sections. The colon section photographs are representative of 6 mice for each group (magnification, ×100). (B) Histological scoring was performed by two experienced pathologists in a blind fashion. Data represent mean histological scores ± SD for n = 6 mice/group. **, P < 0.01 (compared with the results from the PB control group).