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Treatment with 19BQAs induced HSPs in 5Y cells. Immunoblot analysis of biomarkers of Hsp90 inhibition following treatment with BQAs at the indicated concentrations for 16 hours. Note that many 19BQAs induced potent expression of Hsp70 and Hsp27. 19-DMA-GA, 19-dimethylamino-GA; 19-HM-GA, 19-hydroxymethyl-GA; 19-Me-GA, 19-methyl-GA; 19-Ph-Mor-GA, 19-(4-morpholinyl-phenyl)-GA; p-Akt, phosphorylated Akt; 19-Ph-OMe-GA, 19-(4-methoxy-phenyl)-GA; 19-Ph-Ph-GA, 19-(4-phenyl-phenyl)-GA.
