Fig. 8.

19-Ph-GA decreased mTOR activation that was associated with A53T α-Syn–induced toxicity. (A) Post-treatment with 19-Ph-GA for 48 hours significantly blocked the activation of p-mTOR and p-p70S6K induced by A53T α-Syn. (B) Fold changes of LC3 II, p-mTOR, and p-p70S6K levels in (A) are normalized to respective controls and estimated by densitometry. These values are presented as the mean ± S.D. (n = 3); *P < 0.05 is considered significant relative to the control group; #P < 0.05 is considered significant compared with the A53T α-Syn group by one-way analysis of variance using Tukey’s multiple comparison test.