Table 1.
A large proportion of differential footprints occurs in shared DHSs
| Cell type A | Cell type B | DHSs in A | DHSs in B | DHSs shared between A and B | Sites over-footprinted in A | Sites in common DHSs over-footprinted in A | Sites over-footprinted in B | Sites in common DHSs over-footprinted in B |
|---|---|---|---|---|---|---|---|---|
| CD4 | CD8 | 84,830 | 60,890 | 49,365 | 14,772 | 10,600 (71.8) | 3874 | 3584 (92.5) |
| CD4 | CD14 | 84,830 | 109,647 | 47,887 | 14,819 | 6219 (42) | 17,932 | 7663 (42.7) |
| CD4 | CD19 | 84,830 | 89,660 | 43,282 | 18,525 | 10,423 (56.3) | 19,439 | 13,018 (67) |
| CD4 | CD56 | 84,830 | 69,966 | 54,739 | 17,745 | 14,611 (82.3) | 2616 | 2526 (96.6) |
| CD4 | Spinal cord | 84,830 | 197,751 | 34,812 | 24,652 | 9158 (37.1) | 93,152 | 10,233 (11) |
| CD4 | Fibroblasts | 84,830 | 193,546 | 40,240 | 21,473 | 7087 (33) | 118,265 | 11,741 (9.9) |
| CD8 | CD14 | 60,890 | 109,647 | 32,185 | 11,602 | 6529 (56.3) | 55,650 | 12,546 (22.5) |
| CD8 | CD19 | 60,890 | 89,660 | 32,350 | 8780 | 5520 (62.9) | 28,708 | 15,549 (54.2) |
| CD8 | CD56 | 60,890 | 69,966 | 51,965 | 1458 | 1428 (97.9) | 335 | 330 (98.5) |
| CD8 | Spinal cord | 60,890 | 197,751 | 27,631 | 13,128 | 5444 (41.5) | 110,950 | 11,330 (10.2) |
| CD8 | Fibroblasts | 60,890 | 193,546 | 30,237 | 13,734 | 5894 (42.9) | 156,418 | 15,573 (10) |
| CD14 | CD19 | 109,647 | 89,660 | 36,349 | 48,031 | 15,909 (33.1) | 27,111 | 18,140 (66.9) |
| CD14 | CD56 | 109,647 | 69,966 | 33,900 | 54,850 | 17,845 (32.5) | 7842 | 5357 (68.3) |
| CD14 | Spinal cord | 109,647 | 197,751 | 33,141 | 53,731 | 13,584 (25.3) | 96,856 | 13,563 (14) |
| CD14 | Fibroblasts | 109,647 | 193,546 | 45,179 | 37,641 | 8383 (22.3) | 108,482 | 12,677 (11.7) |
| CD19 | CD56 | 89,660 | 69,966 | 35,766 | 31,561 | 19,315 (61.2) | 5553 | 4130 (74.4) |
| CD19 | Spinal cord | 89,660 | 197,751 | 31,858 | 28,993 | 13,118 (45.2) | 97,388 | 14,826 (15.2) |
| CD19 | Fibroblasts | 89,660 | 193,546 | 30,831 | 32,531 | 13,760 (42.3) | 138,301 | 20,224 (14.6) |
| CD56 | Spinal cord | 69,966 | 197,751 | 28,731 | 8633 | 4404 (51) | 110,996 | 13,892 (12.5) |
| CD56 | Fibroblasts | 69,966 | 193,546 | 31,469 | 9237 | 4769 (51.6) | 154,923 | 20,024 (12.9) |
| Spinal cord | Fibroblasts | 197,751 | 193,546 | 64,733 | 24,756 | 5497 (22.2) | 35,202 | 9461 (26.9) |
Number of DHSs and shared DHSs, number of over-footprinted sites, and number of over-footprinted sites located in the overlap of shared DHSs are shown for pairs of cell types. For closely related cell types most differential footprints tend to be found in common DHSs (e.g. CD4+ vs. CD56+). Developmentally distant cell types, however, often have a large number of DHSs that are cell type specific, and therefore the majority of differential footprints are in cell-type specific DHSs (e.g. CD56+ cells vs. fibroblasts)