Table 1.
Clinical characteristics and outcome of sepsis patients stratified according to survival status 30 days after admission
| All patients | Survivors | Non-survivors | P | |
|---|---|---|---|---|
| n = 1103 | n = 786 | n = 305 | ||
| Demographics | ||||
| Age, years, mean (SD) | 61.2 (14.7) | 59.7 (14.7) | 64.9 (13.9) | <0.0001 |
| Gender, male, n (%) | 671 (60.8) | 481 (61.2) | 183 (60) | 0.73 |
| Race, white, n (%) | 972 (88.8) | 689 (87.7) | 273 (89.5) | 0.45 |
| Body mass index, kg/m2, mean (SD) | 26 (6.2) | 26.2 (6.3) | 25.5 (5.8) | 0.09 |
| Admission type, medical, n (%) | 817 (74.1) | 562 (71.5) | 247 (81) | 0.001 |
| Charlson score, median (IQR) | 4 (3–6) | 4 (2–6) | 5 (3–6) | 0.0001 |
| Site of infection | ||||
| Pulmonary, n (%) | 478 (43.3) | 337 (37.1) | 135 (44.3) | 0.69 |
| Abdominal, n (%) | 215 (19.5) | 150 (19.1) | 61 (20) | 0.74 |
| Urinary, n (%) | 109 (9.9) | 84 (10.7) | 24 (7.9) | 0.69 |
| Other, n (%)a | 173 (15.7) | 123 (15.6) | 49 (16.1) | 0.93 |
| Coinfection, n (%) | 128 (11.6) | 92 (11.7) | 36 (11.8) | 1 |
| Severity of disease in first 24 hours | ||||
| APACHE IV score, median (IQR) | 80 (63–101) | 74 (59–92) | 98 (81–122) | <0.0001 |
| SOFA score, median (IQR)b | 7 (5–9) | 7 (4–9) | 9 (6–12) | <0.0001 |
| Shock, n (%) | 373 (33.8) | 234 (29.8) | 135 (44.3) | <0.001 |
| Mechanical ventilation, n (%) | 851 (77.2) | 590 (75.1) | 249 (81.6) | <0.05 |
| Renal replacement therapy, n (%) | 115 (10.4) | 60 (7.6) | 53 (17.4) | <0.001 |
| Outcome | ||||
| ICU length of stay, days, median (IQR) | 4 (2–10) | 5 (2–10) | 3 (2–8) | <0.01 |
| ICU mortality, n (%) | 227 (20.6) | 13 (1.7) | 214 (70.2) | <0.001 |
12 patients were lost to follow up.aSite of infection: “other” includes cardiovascular infection, mediastinitis and skin infection. bCentral nervous system not included in score. APACHE Acute Physiology and Chronic Health Evaluation, SOFA Sequential Organ Failure Assessment