Table 3.
The main pharmacokinetic parameters after oral and intravenous administration of xanthotoxin in rats from non-compartment model
| Parameters | Unit | Mean (± SD) | ||
|---|---|---|---|---|
|
| ||||
| po (20 mg/kg, n = 6) | iv (2 mg/kg, n = 6) | iv (6 mg/kg, n = 6) | ||
| AUC(0-12) | ng/mL*h | 10988.9±2225.7 | 1500.8±486.0 | 4414.2±410.8 |
| AUC(0-∞) | ng/mL*h | 11077.7±2247.4 | 1530.2±507.0 | 4438.3±411.8 |
| MRT(0-12) | h | 5.0±0.6 | 2.4±0.4 | 2.4±0.3 |
| MRT(0-∞) | h | 5.2±0.7 | 2.6±0.5 | 2.5±0.4 |
| t1/2 | h | 3.1±0.2 | 2.5±1.0 | 1.4±0.4 |
| tmax | h | 3.5±1.6 | ||
| CL | L/h/kg | 1.9±0.5 | 2.1±0.6 | 1.4±0.1 |
| V | L/kg | 8.4±2.5 | 7.4±3.4 | 2.7±0.8 |
| Cmax | ng/mL | 1716.8±364.2 | 681.6±318.3 | 1446.8±268.6 |
| Bioavailability | 73.2% | |||