Table 2.
The meta-analysis results of association between IL-10 polymorphisms and lung cancer
| SNPs | Contrast model | OR (95% CI) | P | Test for heterogeneity | Publication bias (Egger‘s test) | ||
|---|---|---|---|---|---|---|---|
|
|
|
||||||
| I2 (%) | P | t | P | ||||
| -592C/A | C vs. A | 1.195 (1.075-1.329) | 0.001 | 35.3 | 0.172 | 0.25 | 0.813 |
| CC vs. AA | 1.651 (1.290-2.113) | 0.000 | 0.0 | 0.562 | 1.01 | 0.372 | |
| CA vs. AA | 1.229 (1.029-1.468) | 0.023 | 30.7 | 0.205 | 1.89 | 0.132 | |
| CA+AA vs. CC | 0.832 (0.704-0.984) | 0.032 | 51.2 | 0.069 | -0.83 | 0.452 | |
| CC+CA vs. AA | 1.301 (1.100-1.538) | 0.002 | 25.6 | 0.242 | 1.69 | 0.167 | |
| -819C/T | C vs. T | 1.441 (1.228-1.691) | 0.000 | 49.7 | 0.114 | -1.83 | 0.210 |
| CC vs. TT | 2.444 (1.732-3.449) | 0.000 | 0.0 | 0.446 | -0.47 | 0.683 | |
| CT vs. TT | 1.220 (0.939-1.586) | 0.137 | 0.0 | 0.663 | 1.25 | 0.337 | |
| CT+TT vs. CC* | 0.638 (0.354-1.151) | 0.136 | 77.0 | 0.005 | 0.50 | 0.667 | |
| CC+CT vs. TT | 1.496 (1.172-1.908) | 0.001 | 0.0 | 0.785 | 0.51 | 0.661 | |
| -1082G/A | A vs. G* | 0.815 (0.626-1.061) | 0.128 | 67.6 | 0.026 | -3.05 | 0.093 |
| AA vs. GG | 0.849 (0.641-1.126) | 0.256 | 48.0 | 0.124 | -1.30 | 0.322 | |
| AG vs. GG | 0.843 (0.651-1.091) | 0.193 | 0.0 | 0.426 | 1.07 | 0.397 | |
| AG+GG vs. AA* | 1.340 (0.855-2.100) | 0.201 | 77.6 | 0.004 | 1.78 | 0.145 | |
| AA+AG vs. GG | 0.839 (0.658-1.070) | 0.158 | 4.7 | 0.369 | -0.17 | 0.881 | |
*
Random-effect model was used.