Table 2.
MICs (μg/mL) from antimicrobial susceptibility testing of 40 international reference rapidly growing mycobacteria
| Sp. (international code) | INH | RFP | EMB | SM | AM | KN | CPM | TOB | OF | CIP | LEV | MOX | LN | SMZ | MIN | DOX | TIG | CLR | FOX | MEM |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| M. chelonae (ATCC35752) | > 256 | > 256 | 128 | 32 | 4 | 16 | 16 | 2 | 32 | 4 | 16 | 4 | 8 | 64 | > 32 | > 32 | 1 | 0.06 | 128 | > 256 |
| M. abscessus (ATCC19977) | > 256 | 64 | 32 | 16 | 1 | 2 | 0.5 | 8 | 4 | 2 | 1 | 1 | 4 | 32 | 8 | 32 | 4 | < 0.03 | 32 | 64 |
| M. bolletii (DSM45149) | > 256 | 32 | 64 | 16 | 0.5 | 0.5 | 1 | 8 | 16 | 4 | 4 | 1 | 2 | 32 | > 32 | 32 | 0.06 | < 0.03 | 32 | 0.25 |
| M. massiliense (DSM45103) | > 256 | 32 | 64 | 2 | 0.13 | 2 | 0.03 | 32 | 0.06 | 0.03 | 0.03 | 0.03 | 4 | 64 | 8 | 0.5 | 0.06 | 0.03 | 64 | 16 |
| M. fortuitum (DSM44220) | 64 | 128 | 256 | 32 | 0.25 | 4 | < 0.03 | 16 | 0.13 | < 0.03 | < 0.03 | < 0.03 | 8 | 2 | 8 | 0.03 | 0. 5 | 1 | 32 | 4 |
| M. senegalense (ATCC35796) | > 256 | 8 | 64 | 4 | 0.5 | 0.25 | 0.13 | 4 | 4 | 4 | 2 | 0.13 | 1 | 16 | 0.25 | 0.06 | 0.03 | 0.13 | 4 | 2 |
| M. boenickei (DSM44677) | 32 | 128 | 4 | 8 | 0.5 | 4 | 0.06 | 4 | 0.5 | 0.25 | 0.25 | 0.06 | 8 | 4 | > 32 | 16 | 0.03 | 16 | 16 | 0.5 |
| M. goodii (DSM44492) | > 256 | 32 | 2 | 32 | 4 | 16 | 0.06 | 32 | 0.5 | 0.5 | 0.25 | 0.06 | 1 | 8 | 2 | 0.5 | 0.13 | > 32 | 8 | 0.25 |
| M. wolinskyi (DSM44493) | > 256 | 64 | 128 | 16 | 0.5 | 2 | 0.13 | 32 | 0.5 | 0.5 | 0.5 | 0.25 | 0.5 | 4 | 1 | 0.13 | 0.25 | > 32 | 32 | 1 |
| M. aichiense (ATCC27280) | > 256 | < 0.25 | 0.5 | < 0.25 | 0.06 | 0.03 | < 0.03 | 0.5 | < 0.03 | < 0.03 | < 0.03 | < 0.03 | 0.5 | 2 | 0.25 | < 0.03 | 0.03 | < 0.03 | 0.5 | 0.25 |
| M. aurum (ATCC23366) | > 256 | 4 | 1 | < 0.25 | 0.25 | 0.06 | < 0.03 | 4 | 0.06 | 0.03 | < 0.03 | < 0.03 | 0.5 | 4 | 0.25 | 0.03 | 0.13 | 0.06 | 16 | 16 |
| M. chubuense (ATCC27278) | > 256 | 1 | 0.5 | 0.5 | 0.25 | 0.03 | < 0.03 | 2 | 0.03 | < 0.03 | < 0.03 | < 0.03 | 0.25 | 1 | 0.25 | 0.13 | 0.13 | < 0.03 | 128 | 16 |
| M. duvalii (ATCC43910) | > 256 | 0.5 | 0.25 | 0.5 | 0.25 | 0.5 | < 0.03 | 2 | 0.06 | < 0.03 | 0.06 | < 0.03 | 0.5 | 8 | 0.5 | 0.03 | 0.06 | 0.5 | 8 | 2 |
| M. flavescens (ATCC14474) | > 256 | 32 | 0.5 | 1 | 0.13 | 0.13 | < 0.03 | 2 | 0.13 | < 0.03 | 0.06 | < 0.03 | 0.5 | 0.5 | 0.5 | 0.06 | 0.03 | 8 | 8 | 64 |
| M. gilvum (ATCC43909) | > 256 | 0.25 | 0.25 | 1 | 0.25 | 0.25 | 0.03 | 1 | 0.13 | < 0.03 | 0.03 | 0.03 | 0.25 | 4 | 0.25 | 0.03 | 0.06 | 0.03 | 4 | 2 |
| M. neoaurum (ATCC25795) | > 256 | 1 | 8 | 0.5 | 0.5 | 0.06 | < 0.03 | 0.25 | 0.06 | 0.06 | 0.03 | < 0.03 | 0.5 | 0.5 | 0.03 | 0.06 | 0.03 | 1 | 8 | 0.5 |
| M. obuense (ATCC27023) | > 256 | 2 | 64 | < 0.25 | 0.13 | 0.13 | < 0.03 | 1 | < 0.03 | < 0.03 | < 0.03 | < 0.03 | 0.5 | 32 | 0.25 | < 0.03 | 0.06 | < 0.03 | < 0.25 | 0.5 |
| M. parafortuitum (ATCC19686) | 0.5 | 2 | 2 | 0.5 | 0.5 | 0.5 | < 0.03 | 0.5 | 0.06 | 0.06 | 0.06 | < 0.03 | 0.5 | 2 | 0.25 | 0.03 | 0.06 | 1 | 4 | 0.25 |
| M. rhodesiae (ATCC27024) | 8 | < 0.25 | < 0.25 | < 0.25 | 0.13 | < 0.03 | < 0.03 | 0.25 | 0.06 | < 0.03 | 0.03 | < 0.03 | 0.25 | 1 | 0.25 | 0.06 | 0.03 | < 0.03 | < 0.25 | 1 |
| M. tokaiense (ATCC27282) | 4 | < 0.25 | 0.5 | 0.5 | 0.25 | 0.25 | < 0.03 | 0.5 | 0.06 | 0.03 | 0.03 | < 0.03 | 0.5 | 8 | 0.25 | 0.13 | 0.03 | 0.13 | 128 | 0.25 |
| M. porcinum (ATCC33776) | 16 | 64 | 64 | 16 | 0.5 | 1 | 0.13 | 2 | 1 | 0.25 | 0.5 | 0.06 | 8 | 4 | 16 | 16 | 0.06 | 2 | 8 | 4 |
| M. pulveris (ATCC35154) | > 256 | 64 | 4 | 2 | 0.5 | 0.13 | 0.03 | 2 | > 32 | 0.5 | 1 | 0.13 | 2 | 256 | 0.25 | 0.06 | 0.03 | 2 | 256 | 1 |
| M. austroafricanum (ATCC33464) | 16 | 1 | 0.5 | < 0.25 | 0.25 | 0.06 | 0.03 | 2 | 0.25 | 0.13 | 0.06 | 0.03 | 0.25 | 256 | 0.25 | 0.03 | 0.13 | <0.03 | 8 | 0.5 |
| M. chitae (ATCC19627) | > 256 | 8 | < 0.25 | 0.5 | 0.13 | 0.03 | < 0.03 | 0.5 | 0.03 | < 0.03 | < 0.03 | < 0.03 | 0.5 | 0.5 | 2 | 0.03 | 0.06 | 4 | 4 | 4 |
| M. aubagnense (DSM45150) | > 256 | 2 | < 0.25 | 1 | 0.06 | 0.5 | < 0.03 | 1 | 0.25 | 0.13 | 0.06 | 0.06 | 0.25 | 1 | 16 | 2 | < 0.03 | < 0.03 | 2 | 0.25 |
| M. brisbanense (DSM44680) | > 256 | 128 | > 256 | 16 | 0.13 | 2 | 0.13 | 8 | 0.5 | 0.25 | 0.25 | 0.06 | 0.5 | 4 | 16 | 4 | 0.13 | 0.13 | 64 | 4 |
| M. brumae (DSM44177) | > 256 | 128 | 64 | 32 | 0.06 | < 0.03 | < 0.03 | 0.5 | < 0.03 | < 0.03 | < 0.03 | < 0.03 | 1 | 2 | 0.25 | < 0.03 | 0.25 | < 0.03 | 64 | 32 |
| M. canariasense (DSM44828) | 16 | 4 | 1 | 0.5 | 0.5 | 0.5 | 0.06 | 0.25 | 0.5 | 0.25 | 0.25 | 0.03 | 0.5 | 0.5 | 0.25 | 0.13 | 0.13 | 0.13 | 4 | 4 |
| M. conceptionense (DSM45102) | > 256 | 128 | 256 | 32 | 0.5 | 1 | 0.06 | 4 | 0.5 | 0.25 | 0.25 | 0.06 | 16 | 128 | 0.5 | 0.13 | < 0.03 | 0.13 | 128 | 0.25 |
| M. confluentis (DSM44017) | > 256 | 8 | 32 | 4 | 0.13 | 0.03 | < 0.03 | 0.25 | 0.03 | < 0.03 | < 0.03 | < 0.03 | 2 | 1 | 1 | 0.06 | 0.25 | 2 | 4 | 2 |
| M. fluoranthenivorans (DSM44556) | > 256 | 0.5 | 0.5 | < 0.25 | 0.06 | 0.13 | < 0.03 | 1 | 0.06 | < 0.03 | 0.03 | < 0.03 | 0.25 | 64 | 0.25 | 0.06 | 0.25 | < 0.03 | 2 | 16 |
| M. moriokaense (DSM44221) | > 256 | 8 | 16 | 8 | 2 | 0.25 | 0.25 | 8 | > 32 | 0.5 | 0.5 | 0.03 | 2 | 64 | 0.25 | 0.03 | 0.03 | 0.5 | 16 | 2 |
| M. mucogenicum (DSM44625) | 0.5 | 32 | 16 | 8 | 1 | 2 | 0.5 | 4 | 2 | 1 | 1 | 0.25 | 2 | 16 | 0.25 | 0.06 | < 0.03 | 0.06 | 16 | 0.25 |
| M. poriferae (DSM44585) | > 256 | 128 | 128 | 16 | 4 | 1 | 0.13 | 8 | 1 | 2 | 2 | 0.13 | 1 | 4 | 0.25 | 0.25 | 0.03 | < 0.03 | 32 | 2 |
| M. pseudoshottsii (DSM45108) | > 256 | 256 | 128 | 32 | 2 | 0.5 | 1 | 4 | 8 | 2 | 4 | 1 | 8 | 4 | 0.25 | 32 | < 0.03 | 0.03 | > 256 | 128 |
| M. psychrotolerans (DSM44697) | 4 | < 0.25 | < 0.25 | < 0.25 | 0.06 | < 0.03 | < 0.03 | 4 | < 0.03 | < 0.03 | < 0.03 | < 0.03 | 0.03 | 0.25 | 1 | 0.13 | 0.03 | < 0.03 | < 0.25 | 2 |
| M. septicum (DSM44393) | 256 | 16 | 4 | 16 | 0.13 | 0.5 | < 0.03 | 1 | 0.25 | 0.06 | 0.13 | 0.06 | 1 | 1 | 32 | 8 | 1 | 1 | 128 | 16 |
| M. setense (DSM45070) | > 256 | 64 | 16 | 8 | 0.5 | 1 | < 0.03 | 4 | 0.25 | 0.06 | 0.13 | 0.03 | 4 | > 256 | > 32 | > 32 | 0.13 | 4 | 16 | 0.25 |
| M. vanbaalenii (DSM7251) | > 256 | 1 | 0.5 | < 0.25 | 0.13 | 0.13 | 0.25 | 1 | 0.25 | 0.13 | 0.13 | 0.03 | 0.25 | 8 | 16 | < 0.03 | 0.25 | < 0.03 | 4 | 64 |
| M. murale (DSM44340) | > 256 | < 0.25 | 0.25 | 0.5 | 0.13 | 1 | < 0.03 | 1 | 0.03 | < 0.03 | < 0.03 | < 0.03 | 0.5 | 2 | 0.25 | 0.13 | 0.13 | 0.06 | 16 | 32 |
| Standard Deviation | 74.64 | 59.64 | 67.62 | 11.78 | 1.05 | 3.62 | 3.54 | 8.36 | 6.1 | 1.3 | 3 | 0.85 | 3.38 | 59.94 | 7.09 | 9.62 | 0.69 | 3.48 | 56.2 | 25.94 |
Note 1: INH: isoniazid, RFP: rifampicin, EMB: ethambutol, SM: streptomycin, AM: amikacin, KN: kanamycin, CPM: capreomycin, TOB: tobramycin, OF: ofloxacin, CIP: ciprofloxacin, LEV: levofloxacin, MOX: moxifloxacin, LN: linezolid, SMZ: sulfamethoxazole, MIN: minocycline, CLR: clarithromycin, DOX: doxycycline, TIG: tigecycline, FOX: cefoxitin, MEM: meropenem. Note 2: Numbers in bold type and underlined indicate sensitive strains; numbers in bold type only indicate moderately sensitive strains. Note 3: M. stands for Mycobacterium.