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Time-course of CYP3A4-catalyzed midazolam 1’-hydroxylation inactivation by salvianolate in HLMs. HLMs were preincubated with salvianolate at 0 (●), 1 (○), or 2 (▼) mg/L in the presence of NADPH for 0 to 30 min. The results shown are the means of triplicate experiments.
