Table 1.

The inhibitory effect of salvianolate on isozyme-specific cytochrome P450 activities in HLMs

CYP isozyme	Specific probe (μM)	Metabolite	Incubation time (min)	Positive control inhibitor concentration (μM)
CYP1A2	Phenacetin (10)	Acetaminophen	30	Furafylline (10)
CYP2A6	Coumarin (5)	7-hydroxycoumarin	20	Tranylcypromine (50)
CYP3A4	Midazolam (5)	1-hydroxymidazolam	30	Ketoconazole (1)
CYP2C9	Tolbutamide (100)	4-hydroxytolbutamide	30	Sulfaphenazole (10)
CYP2C19	S-Mephenytoin (100)	4’-hydroxymephenytoin	30	Ticlopidine (5)
CYP2D6	Metoprolol (7.5)	α-hydroxymetoprolol	15	Quinidine (1)
CYP2E1	Chlorzoxazone (40)	6-Hydroxychlorzoxazone	20	Diethyldithiocarbamate (50)