Table 4.
Correlations between the protein/mRNA expressions of MMP11 and P14ARF with clinical pathological characteristics in 65 LSCC cases
| Factors | Cases (%) | MMP11 | P14ARF | ||
|---|---|---|---|---|---|
|
| |||||
| Protein (+) | High mRNA | Protein (+) | High mRNA | ||
|
| |||||
| N, % | N, % | N, % | N, % | ||
| Age (years) | |||||
| ≥ 60 | 28 (43.1) | 22 (78.6) | 28 (100)a | 10 (35.7) | 8 (28.6) |
| < 60 | 37 (56.9) | 28 (75.7) | 30 (81.1) | 18 (48.6) | 5 (13.5) |
| Gender | |||||
| Male | 58 (89.2) | 45 (77.6) | 52 (89.7) | 25 (43.1) | 12 (20.7) |
| Female | 7 (10.8) | 5 (71.4) | 6 (85.7) | 3 (42.9) | 1 (14.3) |
| Tumor stage | |||||
| I-II | 20 (30.8) | 11 (55.0) | 14 (70.0) | 15 (75.0) | 10 (50.0) |
| III-IV | 45 (69.2) | 39 (86.7)a | 44 (97.8)a | 13 (28.9)a | 3 (6.7)a |
| LNM | |||||
| Absent | 26 (38.2) | 16 (61.5) | 20 (76.9) | 8 (30.8) | 6 (23.1) |
| Present | 39 (61.8) | 34 (87.8)a | 38 (97.4)a | 20 (51.3) | 7 (17.9) |
| Differentiation | |||||
| High | 23 (35.4) | 16 (69.6) | 20 (86.9) | 13 (56.5) | 6 (26.1) |
| M./low | 42 (64.6) | 34 (81.0) | 38 (90.5) | 15 (36.7) | 7 (16.7) |
| Treatment | |||||
| Surgery only | 45 (63.1) | 32 (71.1)a | 43 (95.5)a | 24 (53.3)a | 12 (26.7)a |
| C/X/CX/CXS | 20 (36.9) | 18 (90.0) | 15 (75.0) | 4 (20.0) | 1 (5.0) |
| Smoking | |||||
| Ever | 51 (78.5) | 44 (88.0) | 49 (96.1) | 16 (31.4) | 5 (9.8) |
| Never | 14 (21.5) | 6 (42.9)a | 9 (64.3)a | 12 (85.7)a | 8 (57.1)a |
| Alcohol | |||||
| Ever | 55 (84.6) | 42 (76.4) | 50 (90.9) | 23 (41.8) | 10 (18.2) |
| Never | 10 (15.4) | 8 (80.0) | 8 (80.0) | 5 (50.0) | 3 (30.0) |
a
P < 0.05: significant for either MMP and P14ARF protein or mRNA expressions between then comparison groups for the factors.
LNM: lymph node metastasis; M: moderate; C: chemotherapy; X: radiation; S: surgery.