Table 2.
Meta-analysis of the efficacy of high-dose versus moderate-dose chemotherapy in treating osteosarcoma
| Sample size (n) | Test of association | Test for heterogeneity | |||||
|---|---|---|---|---|---|---|---|
|
|
|||||||
| Genetic model | High-dose | Moderate-dose | RR | 95% CI | P | P | I2 |
| 5-year tumor-free survival | 464 | 459 | 1.11 | 0.95-1.27 | 0.27 | 0.65 | 0% |
| The local recurrence rate | 282 | 264 | 0.94 | 0.54-1.58 | 0.72 | 0.45 | 0% |
| The rate of good local histologic response | 361 | 345 | 0.96 | 0.81-1.24 | 0.32 | 0.64 | 0% |
| 5-year survival | 423 | 405 | 1.09 | 0.97-1.21 | 0.21 | 0.35 | 5.2% |
| Limb salvage rate | 388 | 370 | 0.98 | 0.92-1.05 | 0.18 | 0.93 | 0% |
RR: Relative Risk, CI: confidence interval, vs.: versus.