Table 2.
Univariate analyses of the risk of ≥ grade-2 radiation-induced pneumonitis (RP)
| Risk factor | No RP n (%) | RP n (%) | P-value | OR (95% CI) | β value |
|---|---|---|---|---|---|
| Men | 59 (29.8) | 45 (78.9) | |||
| Women | 25 (70.2) | 12 (21.1) | 0.249 | 0.63 (0.29-1.39) | 0.89 |
| Age < 54 years | 43 (51.2) | 21 (36.8) | |||
| Age ≥ 54 years | 41 (48.8) | 36 (63.2) | 0.093 | 1.80 (0.90-3.58) | 0.59 |
| Smoker | 39 (46.4) | 38 (66.7) | |||
| Nonsmoker | 45 (53.6) | 19 (33.3) | 0.018 | 0.43 (0.22-0.87) | 0.84 |
| Alcohol consumption | 30 (35.7) | 22 (38.6) | |||
| No alcohol consumption | 54 (64.3) | 35 (61.4) | 0.728 | 1.13 (0.56-2.27) | 0.12 |
| KPS: 80-100 | 70 (83.3) | 46 (80.7) | |||
| KPS: 60-70 | 14 (16.7) | 11 (19.3) | 0.688 | 0.84 (0.35-2.00) | -0.18 |
| Lung cancer | 49 (58.3) | 49 (84.2) | 0.003a | ||
| ESCC | 20 (23.8) | 7 (12.3) | 0.029b | 0.36 (0.14-0.92) | -1.03 |
| Mediastinal tumor | 15 (17.9) | 2 (3.5) | 0.004b | 0.14 (0.03-0.63) | -1.99 |
| Surgical resection | 64 (76.2) | 35 (61.4) | |||
| No surgery | 20 (23.8) | 22 (38.6) | 0.060 | 0.50 (0.24-1.03) | -0.69 |
| Chronic pneumonic disease | 9 (10.7) | 7 (12.3) | |||
| No chronic pneumonic disease | 75 (89.3) | 50 (87.7) | 0.774 | 1.17 (0.41-3.34) | 0.15 |
| Chemotherapy | 81 (96.4) | 55 (96.5) | |||
| No chemotherapy | 3 (3.6) | 2 (3.5) | 0.678 | 1.02 (0.17-6.30) | 0.02 |
| Sequential chemotherapy | 76 (90.5) | 42 (73.7) | |||
| Concurrent chemotherapy | 8 (9.5) | 15 (26.3) | 0.008 | 3.40 (1.33-8.66) | 1.22 |
| Total radiation dose ≤ 53 Gy | 44 (52.4) | 21 (36.8) | |||
| Total radiation dose > 53 Gy | 40 (47.6) | 36 (63.2) | 0.008 | 2.59 (1.27-5.27) | 0.95 |
OR, odds ratio; CI, confidence interval; KPS, Karnofsky performance status; ESCC, esophageal squamous cell carcinoma;
a
Comparison of all tumor types;
b
Compared with lung cancer cases.