Table 5.
Associations between the polymorphisms and ≥ grade-2 radiation-induced pneumonitis (RP) in thoracic cancer patients
| SNP | Lung cancer (n = 97) | Esophageal squamous cell carcinoma (n = 27) | Mediastinal cancer (n = 17) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
||||||||||||
| No RP | RP | P-value | OR (95% CI) | No RP | RP | P-value | OR (95% CI) | No RP | RP | P-value | OR (95% CI) | |
| TGF-β1: rs1800470 | ||||||||||||
| TT | 10 (20.4) | 14 (29.2) | 0.403 | 6 (30.0) | 3 (42.9) | 0.081 | 2 (13.3) | 1 (50.0) | 0.174 | |||
| TC | 30 (61.2) | 29 (60.4) | 0.69 (0.27-1.80) | 7 (35.0) | 4 (57.1) | 1.14 (0.18-7.28) | 9 (60.0) | 0 (0) | NC | |||
| CC | 9 (18.4) | 5 (10.4) | 0.40 (0.10-1.55) | 7 (35.0) | 0 (0) | NC | 4 (26.7) | 1 (50.0) | 0.50 (0.02-12.90) | |||
| T | 51.0 | 59.4 | 0.2349 | 47.5 | 71.4 | 0.0006 | 43.3 | 50.0 | 0.3447 | |||
| C | 49.0 | 40.6 | 52.5 | 28.6 | 56.7 | 50.0 | ||||||
| TGF-β1: rs1800469 | ||||||||||||
| TT | 11 (22.4) | 16 (33.3) | 0.453 | 9 (45.0) | 5 (71.4) | 0.444 | 1 (6.7) | 1 (50.0) | 0.126 | |||
| CT | 30 (61.2) | 24 (50.0) | 0.55 (0.22-1.40) | 7 (350) | 1 (14.3) | 0.26 (0.02-2.73) | 9 (60.0) | 0 (0) | NC | |||
| CC | 8 (16.3) | 8 (16.7) | 0.69 (0.20-2.39) | 4 (20.0) | 1 (14.3) | 0.45 (0.04-5.21) | 5 (33.3) | 1 (50.0) | 0.20 (0.01-0.67) | |||
| T | 53.1 | 58.3 | 0.453 | 62.5 | 78.6 | 0.0127 | 36.7 | 50.0 | 0.0571 | |||
| C | 46.9 | 41.7 | 37.5 | 21.4 | 63.3 | 50.0 | ||||||
| ATM: rs189037 | ||||||||||||
| GG | 14 (28.6) | 15 (31.2) | 0.909 | 4 (20.0) | 3 (42.9) | 0.515 | 2 (13.3) | 0 (0) | 0.667 | |||
| GA | 22 (44.9) | 22 (45.8) | 0.89 (0.37-2.38) | 12 (60.0) | 3 (42.9) | 0.33 (0.05-2.37) | 9 (60.0) | 1 (50.0) | NC | |||
| AA | 13 (26.5) | 11 (22.9) | 0.79 (0.27-2.34) | 4 (20.0) | 1 (14.3) | 0.33 (0.02-4.74) | 4 (26.7) | 1 (50.0) | NC | |||
| G | 51.0 | 54.2 | 0.6559 | 50.0 | 64.3 | 0.0412 | 43.3 | 25.0 | 0.0063 | |||
| A | 49.0 | 45.8 | 50.0 | 35.7 | 56.7 | 75.0 | ||||||
| ATM: rs373759 | ||||||||||||
| GG | 19 (38.8) | 18 (37.5) | 0.944 | 8 (40.0) | 3 (42.9) | 0.991 | 4 (26.7) | 0 (0) | 0.527 | |||
| GA | 24 (49.0) | 23 (47.9) | 1.01 (0.43-2.40) | 9 (45.0) | 3 (42.9) | 0.89 (0.14-5.72) | 7 (46.7) | 1 (50.0) | NC | |||
| AA | 6 (12.2) | 7 (14.6) | 1.23 (0.35-4.37) | 3 (15.0) | 1 (14.3) | 0.89 (0.06-12.25) | 4 (26.7) | 1 (50.0) | NC | |||
| G | 63.3 | 61.5 | 0.792 | 62.5 | 64.3 | 0.7932 | 50.0 | 25.0 | 0.0003 | |||
| A | 36.7 | 38.5 | 37.5 | 35.7 | 50.0 | 75.0 | ||||||
SNP, single-nucleotide polymorphism; OR, odds ratio; CI, confidence interval; NC, not calculated. Multivariate analyses in this table were adjusted for smoking status, chronic pneumonic disease, total radiation dose and the type of chemotherapy.