Table 2.
Associations between candidate RAD52 genetic variants and SCLC risk in Huaian case-control set (Training set)
| No. | rs ID | Base change | MAF1 | Genotypes (200 SCLC cases and 400 healthy controls) | ||||
|---|---|---|---|---|---|---|---|---|
|
| ||||||||
| Common2 | Heterozygous2 | Rare2 | OR (95% CI)3 | P 3 | ||||
| 1 | rs10849605 | C > T | 0.665 | 25/50 | 82/168 | 93/182 | 0.98 (0.75-1.27) | 0.862 |
| 2 | rs1051669 | G > A | 0.190 | 134/271 | 55/106 | 11/23 | 0.98 (0.72-1.35) | 0.917 |
| 3 | rs10774474 | A > T | 0.307 | 94/188 | 90/178 | 15/34 | 0.12 (0.78-1.34) | 0.859 |
| 4 | rs11571378 | T > A | 0.225 | 121/236 | 70/147 | 8/16 | 1.04 (0.77-1.41) | 0.768 |
| 5 | rs7963551 | C > A | 0.206 | 161/258 | 34/119 | 5/23 | 0.48 (0.33-0.69) | 3.4×10-5 |
| 6 | rs6489769 | T > C | 0.500 | 51/100 | 99/200 | 50/100 | 1.02 (0.80-1.31) | 0.870 |
Abbreviations: SCLC, small cell lung cancer; OR, odds ratio; CI, confidence interval.
1
MAF in healthy controls.
2
Number of SCLC case/number of control.
3
Allelic OR calculated by logistic regression.