Table 3.
Genotype frequencies of RAD52 rs7963551 C > A genetic variant among patients and controls and their association with SCLC risk
| Genotypes | RAD52 rs7963551 C > A | ||||
|---|---|---|---|---|---|
|
| |||||
| Patients No. (%) | Controls No. (%) | OR (95% CI)a | P-value | ||
| Huaian set | n = 200 | n = 400 | |||
| CC | 161 (80.5) | 258 (64.5) | Reference | ||
| CA | 34 (17.0) | 119 (29.8) | 0.38 (0.24-0.62) | 1.1×10-4 | |
| AA | 5 (2.5) | 23 (5.7) | 0.64 (0.36-1.11) | 0.113 | |
| Jinan set | n = 320 | n = 640 | |||
| CC | 234 (73.1) | 415 (64.8) | Reference | ||
| CA | 78 (24.4) | 199 (31.1) | 0.69 (0.49-0.97) | 0.032 | |
| AA | 8 (2.5) | 26 (4.1) | 0.74 (0.48-1.13) | 0.162 | |
| Total | n = 520 | n = 1040 | |||
| CC | 395 (76.0) | 673 (64.7) | Reference | ||
| CA | 112 (21.5) | 318 (30.6) | 0.53 (0.43-0.74) | 4.7×10-5 | |
| AA | 13 (2.5) | 49 (4.7) | 0.69 (0.49-0.97) | 0.032 | |
Abbreviations: SCLC, small cell lung cancer; OR, odds ratio; CI, confidence interval.
a
Data were calculated by logistic regression with adjustment for age, sex and smoking status.