Table 2.
Association of genetic variants in ApoB gene with risk of MI
| SNP | Controls, n (%) | Cases, n (%) | OR (95% CI)† | OR (95% CI)‡ | P value |
|---|---|---|---|---|---|
| rs676210 | |||||
| AA | 280 (50.9) | 245 (44.5) | 1.00 | 1.00 | |
| AG | 235 (42.7) | 246 (44.7) | 1.20 (0.93-1.53) | 1.19 (0.92-1.54) | 0.16 |
| GG | 35 (6.4) | 59 (10.7) | 1.93 (1.23-3.03) | 1.89 (1.18-3.03) | 0.005 |
| AG+GG | 270 (49.1) | 305 (55.5) | 1.29 (1.02-1.64) | 1.28 (1.00-1.64) | 0.04 |
| rs679899 | |||||
| AA | 385 (70.0) | 380 (69.1) | 1.00 | 1.00 | |
| AG | 153 (27.8) | 154 (28.0) | 1.02 (0.78-1.33) | 0.99 (0.75-1.31) | 0.89 |
| GG | 12 (2.2) | 16 (2.9) | 1.34 (0.63-2.88) | 1.65 (0.75-3.65) | 0.45 |
| AG+GG | 165 (30.0) | 170 (30.9) | 1.04 (0.81-1.35) | 1.04 (0.79-1.36) | 0.75 |
| rs2854725 | |||||
| TT | 404 (73.5) | 388 (70.5) | 1.00 | 1.00 | |
| TG | 139 (25.3) | 147 (26.7) | 1.10 (0.84-1.44) | 1.09 (0.82-1.45) | 0.49 |
| GG | 7 (1.3) | 15 (2.7) | 2.23 (0.90-5.53) | 2.11 (0.82-5.40) | 0.08 |
| TG+GG | 146 (26.6) | 162 (29.4) | 1.16 (0.89-1.50) | 1.15 (0.87-1.51) | 0.28 |
| rs11676704 | |||||
| TT | 284 (51.6) | 281 (51.1) | 1.00 | 1.00 | |
| TG | 215 (39.1) | 216 (39.3) | 1.01 (0.79-1.30) | 1.02 (0.79-1.33) | 0.91 |
| GG | 51 (9.3) | 53 (9.6) | 1.05 (0.69-1.59) | 1.13 (0.73-1.74) | 0.83 |
| TG+GG | 266 (48.4) | 269 (48.9) | 1.02 (0.81-1.29) | 1.04 (0.81-1.34) | 0.86 |
| rs3791980 | |||||
| GG | 304 (55.3) | 302 (54.9) | 1.00 | 1.00 | |
| GT | 205 (37.3) | 206 (37.5) | 1.01 (0.79-1.30) | 1.00 (0.77-1.30) | 0.92 |
| TT | 41 (7.5) | 42 (7.6) | 1.03 (0.65-1.63) | 0.97 (0.60-1.57) | 0.90 |
| GT+TT | 246 (44.7) | 248 (45.1) | 1.02 (0.80-1.29) | 1.00 (0.78-1.28) | 0.90 |
| rs512535 | |||||
| CC | 396 (72.0) | 392 (71.3) | 1.00 | 1.00 | |
| CT | 144 (26.2) | 147 (26.7) | 1.03 (0.79-1.35) | 1.04 (0.78-1.38) | 0.81 |
| TT | 10 (1.8) | 11 (2.0) | 1.11 (0.47-2.64) | 1.03 (0.41-2.61) | 0.81 |
| CT+TT | 154 (28.0) | 158 (28.7) | 1.04 (0.80-1.35) | 1.04 (0.79-1.37) | 0.78 |
| rs12720841 | |||||
| TT | 486 (88.4) | 470 (85.5) | 1.00 | 1.00 | |
| TC | 64 (11.6) | 80 (14.6) | 1.29 (0.91-1.84) | 1.36 (0.94-1.97) | 0.15 |
| CC | - (-) | - (-) | - | - | - |
| rs2678379 | |||||
| AA | 293 (53.3) | 270 (49.1) | 1.00 | 1.00 | |
| AG | 216 (39.3) | 226 (41.1) | 1.13 (0.88-1.46) | 1.14 (0.88-1.48) | 0.32 |
| GG | 41 (7.5) | 54 (9.8) | 1.43 (0.92-2.21) | 1.40 (0.88-2.22) | 0.11 |
| AG+GG | 257 (46.7) | 280 (50.9) | 1.18 (0.93-1.50) | 1.18 (0.92-1.52) | 0.17 |
†
Adjusted for age.
‡
Adjusted for age, smoking, diabetes, hypertension and BMI.