Table 3.
Distribution of genotype and allele frequencies in NSCLC patients and controls
| Genotypes | Cases, n (%) | Controls, n (%) | OR (95% CI) | P value |
|---|---|---|---|---|
| CTLA-4+49 | ||||
| AA | 172 (32.6) | 222 (37.0) | 1 | |
| GA | 282 (53.4) | 306 (51.0) | 1.19 (0.92-1.54) | 0.185 |
| GG | 74 (14.0) | 72 (12.0) | 1.33 (0.91-1.94) | 0.146 |
| A | 626 (59.3) | 750 (62.5) | 1 | |
| G | 430 (40.7) | 450 (37.5) | 1.15 (0.97-1.36) | 0.118 |
| CTLA-4-318 | ||||
| CC | 468 (88.6) | 510 (85.0) | 1 | |
| CT | 60 (11.4) | 90 (15.0) | 0.73 (0.51-1.03) | 0.074 |
| TT | 0 | 0 | ||
| C | 996 (94.3) | 1110 (92.5) | 1 | |
| T | 60 (5.7) | 90 (7.5) | 0.74 (0.53-1.04) | 0.085 |
| PD-1.1 | ||||
| GG | 144 (27.3) | 156 (26.0) | 1 | |
| GA | 246 (46.6) | 296 (49.3) | 0.90 (0.68-1.19) | 0.467 |
| AA | 138 (26.1) | 148 (24.7) | 1.01 (0.73-1.40) | 0.951 |
| G | 534 (50.6) | 608 (50.7) | 1 | |
| A | 522 (49.4) | 592 (49.3) | 1.00 (0.85-1.19) | 0.963 |
| PD-1.3 | ||||
| GG | 426 (80.7) | 456 (76.0) | 1 | |
| GA | 102 (19.3) | 142 (23.7) | 0.77 (0.58-1.02) | 0.072 |
| AA | 0 | 2 (0.3) | ||
| G | 954 (90.3) | 1054 (87.8) | 1 | |
| A | 102 (9.7) | 146 (12.2) | 0.77 (0.59-1.00) | 0.058 |
| PD-1.5 | ||||
| CC | 244 (46.2) | 256 (42.7) | 1 | |
| CT | 216 (40.9) | 246 (41.0) | 0.92 (0.72-1.19) | 0.526 |
| TT | 68 (12.9) | 98 (16.3) | 0.73 (0.51-1.04) | 0.080 |
| C | 704 (66.7) | 758 (63.2) | 1 | |
| T | 352 (33.3) | 442 (36.8) | 0.86 (0.72-1.02) | 0.083 |
| PD-1.9 | ||||
| CC | 343 (65.0) | 404 (67.3) | 1 | |
| CT | 148 (28.0) | 168 (28.0) | 1.04 (0.80-1.35) | 0.784 |
| TT | 37 (7.0) | 28 (4.7) | 1.56 (0.93-2.60) | 0.090 |
| C | 834 (79.0) | 976 (81.3) | 1 | |
| T | 222 (21.0) | 224 (18.7) | 1.16 (0.94-1.43) | 0.161 |
| PD-L1 8293 | ||||
| AA | 416 (78.8) | 512 (85.3) | 1 | |
| AC | 106 (20.1) | 84 (14) | 1.55 (1.13~2.13) | 0.006 |
| CC | 6 (1.1) | 4 (0.7) | 1.85 (0.52~6.59) | 0.345 |
| A | 938 (88.8) | 1108 (92.3) | 1 | |
| C | 118 (11.2) | 92 (7.7) | 1.52 (1.14~2.04) | 0.004 |