Table 3.

Differential DNA methylation between African-American and European-American lupus patients in CpG sites identified to be differentially hypomethylated in healthy African-Americans and located in genes connected to lupus using IRIDESCENT literature mining analysis

CpG site	Associated gene	African-American average β	European-American average β	Δβ	P value	Location (chromosome: HG19 position)
cg12080831	GLI2	0.35	0.47	−0.13	7.92E−14	2:121697428
cg23112188	PCK2	0.31	0.46	−0.15	3.05E−12	14:24563095
cg22816218	RIPK1	0.71	0.85	−0.13	3.05E−12	6:3091462
cg12091331	PLAT	0.64	0.74	−0.10	3.05E−12	8:42065314
cg15844419	COL18A1	0.69	0.81	−0.12	1.35E−08	21:46850665
cg27509823	RC3H1	0.74	0.82	−0.08	1.18E−07	1:173930183
cg06193043	NPPA	0.64	0.74	−0.10	5.32E−06	1:11908199
cg00471190	IL32	0.23	0.36	−0.13	6.86E−06	16:3115809
cg00239353	IL32	0.53	0.72	−0.19	7.62E−06	16:3115133
cg20135711	ITGB7	0.70	0.80	−0.10	2.13E−05	12:53592259
cg17330251	PON1	0.49	0.62	−0.13	9.24E−05	7:94953956
cg23813257	IL32	0.24	0.32	−0.08	1.06E−04	16:3115286
cg01874867	PON1	0.45	0.57	−0.12	1.35E−04	7:94954059
cg19678392	PON1	0.55	0.66	−0.11	1.70E−04	7:94953810
cg20768743	CD226	0.17	0.24	−0.07	2.24E−04	18:67624846
cg04871131	PON1	0.62	0.72	−0.10	3.28E−04	7:94954202
cg08978665	IL32	0.31	0.40	−0.10	4.00E−04	16:3115707
cg09035930	SLC15A4	0.67	0.77	−0.11	7.40E−04	12:129282057
cg20119798	PON1	0.50	0.61	−0.10	7.68E−04	7:94954144
cg22216157	PTPRN2	0.68	0.79	−0.10	7.68E−04	7:157643037
cg24425727	CDKN1A	0.28	0.35	−0.06	2.81E−02	6:36645648
cg04548204	KLRG1	0.37	0.45	−0.08	5.99E−02	12:9162872
cg27473997	USP17	0.73	0.78	−0.05	9.89E−02	4:9355351
cg22798247	TAP2	0.84	0.86	−0.02	9.89E−02	6:32807372
cg18938907	GSTM1	0.28	0.22	0.05	3.83E−01	1:110230456
cg11680055	GSTM1	0.23	0.25	−0.02	5.38E−01	1:110230252
cg24506221	GSTM1	0.19	0.21	−0.02	7.71E−01	1:110230401
cg10950028	GSTM1	0.39	0.40	0.00	9.09E−01	1:110230633