Table 5.

The interaction between APOE ε4 and age on cognition by other domains (Step 3)

	B	SE B	t	P	95% Confidence Interval
					Lower	Upper
Working memory
Agea	−0.02	0.01	−2.31	0.02	−0.03	−0.003
Sexb	0.04	0.15	0.26	0.80	−0.25	0.33
Ethnicityc	0.34	0.11	3.14	<0.01	0.13	0.55
Cognitive reserve	0.03	0.004	5.69	<0.001	0.02	0.03
ε4 alleled	−0.09	0.14	−0.64	0.53	−0.37	0.19
ε4 allele x age	−0.02	0.01	−1.17	0.24	−0.05	0.01
Information Processing Speed
Agea	−.02	0.01	−3.18	0.002	−0.04	−.01
Sexb	0.11	0.13	0.90	0.37	−0.13	0.36
Ethnicityc	0.12	0.09	1.33	0.19	−0.06	0.31
Cognitive reserve	0.02	0.004	4.28	<0.001	0.01	0.02
ε4 alleled	−0.21	0.12	−1.68	0.09	−0.45	0.04
ε4 allele x age	−0.02	0.01	−1.54	0.13	−0.04	0.01
Learning
Agea	−0.01	0.01	−1.50	0.14	−0.03	0.004
Sexb	0.09	0.14	0.65	0.52	−0.18	0.36
Ethnicityc	0.23	0.10	02.19	0.03	0.02	0.43
Cognitive reserve	0.02	0.004	04.63	<0.001	0.01	0.03
ε4 alleled	−0.20	0.14	−1.50	0.14	−0.47	0.06
ε4 allele x age	−0.02	0.01	−1.20	0.23	−0.04	0.01
Memory
Agea	−0.01	0.01	−1.41	0.16	−0.03	0.004
Sexb	0.08	0.14	0.56	0.58	−0.20	0.36
Ethnicityc	0.21	0.10	1.99	0.05	0.002	0.41
Cognitive reserve	0.02	0.004	4.55	<0.001	0.01	0.03
ε4 alleled	−0.13	0.14	−0.94	0.35	−0.40	0.14
ε4 allele x age	−0.02	0.01	−0.09	0.27	−0.04	0.01

Note:

^aCentered at 50 years;

^bReference group is male;

^cReference group is ethnic minority;

^dReference group is ε4–.

Abbreviation: SE, standard error.