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. Author manuscript; available in PMC: 2016 Jan 1.
Published in final edited form as: Curr Pharm Des. 2015;21(36):5267–5276. doi: 10.2174/1381612821666150915104529

Figure 1.

Figure 1

Representative images detecting early stage atherosclerosis. (A) SPECT/CT imaging showed uptake of 99mTc-cAbVCAM1-5 in the aortic arch of C57Bl/6J and apoE-/- mice in coronal views, demonstrating higher signal as compared to non-specific control nanobody 99mTc-cAbBcll10. (B) Planar images after injection of 99mTc-B2702p1, 99mTc-B2702p1 mismatch and 99mTc-B2702p with higher left carotid uptake indicated by white arrow. (C) 68Ga-DOTA-FAMP peptide uptake in PET imaging of Japanese white (JW) control rabbit and WHHL-MI, without and with stent implanted presenting high uptake by atherosclerosis model which was more significant with the presence of the stent. (D) PET/CT images of 64Cu-DOTA-DAPTA-comb detecting plaque at right femoral arteries of apoE-/- mice 1, 4, 24 and 48 hours post injection, demonstrating increasing uptake over time. Images modified with permission [33, 36, 38, 85].