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. Author manuscript; available in PMC: 2016 Jan 1.
Published in final edited form as: Curr Pharm Des. 2015;21(36):5267–5276. doi: 10.2174/1381612821666150915104529

Figure 2.

Figure 2

Representative images using antibodies as radiotracers for atherosclerosis imaging. (A) In vivo PET/CT imaging in LDLR-/- mice injected with 64Cu-DOTA-anti-P-selectin mAb, demonstrating signal uptake in the brachiocephalic artery and aortic arch, as indicated by arrowhead and arrow, respectively. (B) Planar images after injection 99mTc-LOX-1-mAb compared to 99mTc-IgG2a in WHHL-MI and control rabbits. White arrows indicate aorta, K is kidney, L is liver, S is spleen. (C) Noninvasive planar images with injection of 99mTc-chP3R99 mAb by atherosclerotic (left image) and healthy (center image) rabbits, demonstrating the accumulation in the carotid indicated by arrowheads, compared to the injection of control radiotracer 99mTc-chT3 mAb (right image). Modified with permission [39, 41, 42].