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. Author manuscript; available in PMC: 2016 Jan 1.
Published in final edited form as: Curr Pharm Des. 2015;21(36):5267–5276. doi: 10.2174/1381612821666150915104529

Figure 5.

Figure 5

Studies involving multimodal imaging agents and new hybrid systems. (A) PET/CT imaging with 64Cu-TNP with uptake in aortic arch demonstrated by arrow, MRI images showing signal in the aortic root pre and post-injection, respectively and versatility of the tracer showed by ex vivo near-infrared fluorescence reflectance imaging (NIRF) of the aorta with signal observed in the root (arrow) and carotid bifurcation (arrowhead). (B) Uptake of 89Zr-DNP in atherosclerotic plaque of aortic root from apoE-/- mice. Hybrid PET/MRI (top) and MRI (bottom) images demonstrating the signal from radiotracer and Oil-Red O staining and autoradiography of aorta correlating uptake in PET/MRI imaging. (C) PET/CT images in axial views demonstrating uptake of (LyP-1)4-dendrimer-6-BAT-64Cu and (ARAL)4-dendrimer-6-BAT-64Cu in the aortic root (AR) and descending aorta (DA). Modified with permission [50-52].