Box-and-whisker plots depicting the dependence of pore size of hollow fiber bundles with flow rate and production time. (a) Core flow rate (0.8 mL/h, 1.0 mL/h and 1.4 mL/h); (b) production time (0.5 h, 1.0 h and 2.0 h). Median values, interquartile ranges (i.q.r.) and 1.5 times the i.q.r (excluding outliers ° and extreme values *) are denoted by horizontal bars, boxes and whiskers respectively. There were statistically significant changes in pore sizes with the increasing core flow rate and production time (Kruskal–Wallis, p < 0.01).