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. Author manuscript; available in PMC: 2015 Nov 25.
Published in final edited form as: Biomaterials. 2015 Mar 29;54:63–71. doi: 10.1016/j.biomaterials.2015.03.019

Fig. 3.

Fig. 3

Tumor-associated Fn matrices are thicker, denser, and comprised thicker fibers. (A) Tumor-associated Fn matrices (n = 21) measured by the SFA were thicker than control matrices (n = 17). (B) Z-projections of immunostained control and tumor-associated Fn matrices. Scale bars = 50 µm. Insets: 300% zooms used to determine the pore size and fiber diameter shown in panels (C) and (D), respectively. (C) Pores measured within tumor-associated Fn matrices (n = 72) were significantly smaller than those measured within control matrices (n = 72) (p < 0.0001). (D) Tumor-associated Fn fibers (n = 120) possessed larger diameters than those of control Fn fibers (n = 120) (p < 0.05). Mean ± SD.