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. Author manuscript; available in PMC: 2016 Nov 1.
Published in final edited form as: Free Radic Biol Med. 2015 Jun 27;88(0 0):108–146. doi: 10.1016/j.freeradbiomed.2015.06.021

Fig. 4.

Fig. 4

Structure of CNC-bZIP family members. By definition, all family members contain both CNC and bZIP sequences, which together comprise the Neh1 domain. The Neh2 or the Neh2-like (Neh2L) domain is present in mammalian Nrf1 and Nrf2 as well as the Drosophila CNC protein. The Neh3, Neh5, and Neh6 domains are common to all family members. The Neh4 domain is represented only in Nrf2 and CNC. The Neh7 domain has to date been identified only in Nrf2. An N-terminal domain (NTD) is found in Nrf1, Nrf3, and CNC, which directs them to the endoplasmic reticulum.