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. Author manuscript; available in PMC: 2016 Nov 1.
Published in final edited form as: Free Radic Biol Med. 2015 Jun 27;88(0 0):108–146. doi: 10.1016/j.freeradbiomed.2015.06.021

Fig. 5.

Fig. 5

The antioxidant response element. The characteristics of ARE sequences across human and rodent genes, and Nrf2-binding profiles, have been assessed using bioinformatics. (A) The ARE consensus sequence as usually reported in the literature on the basis of mutation analyses of gene reporter plasmids based primarily on rat, mouse, and human GST and NQO1 genes. (B and C) The positional matrices for the human and murine ARE sequences, Jasper IDs MA0150.1 and MA0150.2, respectively, which have been generated by the frequency at which these sites have been found experimentally to be occupied by Nrf2.