Table 1.
miRNAs regulated by chemopreventive agents
| Compound | Experimental model | miRNA | Comments | Ref |
|---|---|---|---|---|
| Butyrate | HCT-116 cells | imR-106b↓ | Induce p21 expression | [91] |
| Curcumin | MCF7 cells | miR-15a↑, miR-16↑ | induce apoptosis | [92] |
| A549/DDP cells | miR-136↓, miR-186*↓ | induce apoptosis | [93] | |
| BxPC-3 cells | miR-22↑, miR-199a*↓ | anti-tumorigenesis | [94] | |
| Gemcitabine-resistant MIAPaCa cells and BxPC-3 cells | miR-200↑, miR-21↓ | curcumin and analogue CDF | [95] | |
| EGCG | HepG2 cells | miR-16↑, let-7 family↑, miR-20a↑, miR-221↑, miR-125b↓ | anti-proliferation | [96] |
| PCa xenograft | miR-330↑, miR-21↓ | inhibit tumor growth | [97] | |
| Ellagitannin | HepG2 cells | let-7e↑, miR-370↑, miR-373*↑, and miR-526b↑ | [98] | |
| Genistein | PC3 cells | miR-221↓, miR-222↓ | up-regulation of ARHI | [99] |
| PC3 cells | miR-1296↑ | repression of MCM2 | [100] | |
| C918 cells (human uveal melanoma) | miR-27a↓ | up-regulation of ZBTB10 | [101] | |
| Colo357 and Panc-1 cells | miR-146a↑ | inhibition of pancreatic cancer cell invasion | [102] | |
| I3C/DIM | Vinyl carbamate-induced mouse lung tumors | miR-21↓, mir-31↓, miR-130a↓, miR-146b↓, miR-377↓ | [103] | |
| Rats exposed to cigarette smoke | let-7c↑ | I3C alone and combine with PEITC | [104] | |
| MiaPaCa-2, Panc-1, and Aspc-1 cells | miR-200↑ | reversal of EMT | [105] | |
| Colo357 and Panc-1 cells | miR-146a↑ | inhibition of pancreatic cancer cell invasion | [102] | |
| PEITC | Rats exposed to cigarette smoke, lung tissues | let-7a↑, let-7c↑, miR-99b↑, miR-123↑, miR-146↑, miR-192↑, miR-222↑ | [104] | |
| Mice exposed to cigarette smoke, lung and liver tissues | let-7a↑, let-7c↑, miR-26a↑, miR-125b↑, miR-29b↓, miR-31↓, miR-135b, miR-200b↓, miR-382↓ | [106] | ||
| n-3 PUFAs | Rat AOM model, HCT-116 cells | let-7d↑, miR-15b↑, miR-107↑, miR-191↑, miR-324-5p↑ | [107] | |
| Quercetin | RAW264.7 cells | miR-155↓ | Anti-inflammaton | [51] |
| Mice liver | miR-122↑, miR-125b↑ | [108] | ||
| Resveratrol | SW480 cells | miR-146-5p↑, miR-1↑, miR-17↓, miR-21↓, miR-25↓, miR-92a-2↓, miR-17-92↓ | [109] | |
| THP-1 cells, human blood monocytes | miR-663↑, miR-155↓ | [110] | ||
| Vitamin A | Acute promyelocytic leukemia NB4 cells | miR-15a↑, miR-15b↑, miR-16-1↑, let-7a-3↑, let-7c↑, let-7d↑, miR-223↑, miR-342↑, miR-107↑, miR-181b↓ | [1] | |
| Vitamin E | VE-deficiency rat liver | miR-122a↓, miR-125b↓ | [111] |