Table 3.

Summary of selected endovascular CBUS devices, their design features, performance evaluations and clinical utilizations.

CBUS Device	General Design Features	Performance	Site-Specific Evaluations	Clinical Utilization
Endovascular: pulmonary vein isolation	Endocardial access for placement within pulmonary vein; single tubular transducer, 6 - 8 MHz; Delivery catheter: 2.7-4.7 mm OD; Cooling balloon; multi-chamber balloon w/parabolic reflector.	Penetration depth ∼ 6 mmCT/Fluoroscopic guidance during endocardial access.	Ablation of tissue around pulmonary vein ostium: in vivo canine [90]	Treatment of atrial fibrillation [91, 95, 96]
Endovascular: renal denervation	Configured for vascular placement within renal artery; 360 deg tubular transducer, 1mm OD × 6 mm long transducer, 8-9 MHz; 2 mm OD catheter w/6 mm expandable cooling balloon	Penetration depth ∼ 7 - 10 mm × 360 deg., with sparing of renal artery; fluoroscopic guidance;	Ablation of sympathetic nerves surrounding renal artery, decrease in blood pressure; In vivo porcine [99]	Treatment of resistant hypertension [98]