Table 1. RMSF of the A-loop region and IC₅₀ values of imatinib for the studied tyrosine kinases and the designed triple mutants of Src.

TK	A-loop RMSF (Å)	IC50 (μM)
Abl	4.2	0.037 [58]
E450K	4.85	2.3 [16]
T315I	2.5	6.4 [59]
H396P	2.15	9 [17]
E279K	2.6	9.9 [16]
G250E	1.8	>20 [16, 54]
Kit	5.5	0.3 [55]
Lck	3.2	9 [56]
Met	2.6	>100 [5]
EGFR	2.5	>100 [57]
Src	2	>100 [5, 57]