Table 3. The association between selected medical conditions and breast cancer risks.
| Conditional Logistic Regression | Define disease ≥1 year prior index date | Further exclude cases who had prior cancer history | Further adjust for occupation, screening, and the average outpatient visit per year | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Control | Case | OR | 95% CI | Control | Case | OR | 95% CI | Control | Case | OR | 95% CI | OR | 95% CI | |
| Breast disease | 3,131 | 1,897 | 18.0 | (16.4, 19.8) | 1,705 | 967 | 2.67 | (2.45, 2.92) | 1,668 | 943 | 2.66 | (2.43, 2.91) | 2.47 | (2.26, 2.71) |
| Benign neoplasm of breast | 411 | 1,104 | 13.5 | (11.9, 15.3) | 353 | 263 | 3.12 | (2.65, 3.68) | 339 | 253 | 3.11 | (2.63, 3.68) | 2.90 | (2.46, 3.43) |
| Disorders of breast | 1,602 | 2,402 | 11.6 | (10.1, 12.7) | 1,447 | 798 | 2.50 | (2.28, 2.75) | 1,417 | 780 | 2.50 | (2.27, 2.75) | 2.31 | (2.10, 2.55) |
| Alcohol-related diagnosis | 119 | 37 | 1.10 | (0.67, 1.80) | 109 | 33 | 1.15 | (0.69, 1.92) | 108 | 33 | 1.22 | (0.83, 1.81) | 1.12 | (0.67, 1.87) |
| Metabolic disorders (any 3 of the following) | 1,258 | 365 | 1.19 | (1.05, 1.35) | 1,080 | 312 | 1.18 | (1.03, 1.35) | 1,043 | 300 | 1.17 | (1.02, 1.35) | 1.09 | (0.95, 1.26) |
| Hypertensive diseases | 5,471 | 1,545 | 1.26 | (1.17, 1.37) | 5,065 | 1,409 | 1.22 | (1.12, 1.32) | 4,904 | 1,357 | 1.20 | (1.11, 1.31) | 1.14 | (1.05, 1.25) |
| Diabetes mellitus | 2,658 | 758 | 1.19 | (1.08, 1.30) | 2,433 | 685 | 1.16 | (1.06, 1.28) | 2,357 | 663 | 1.16 | (1.05, 1.28) | 1.09 | (0.98, 1.20) |
| Disorders of lipoid metabolism | 3,766 | 1,101 | 1.26 | (1.16, 1.36) | 3,388 | 992 | 1.25 | (1.15, 1.36) | 3,273 | 958 | 1.25 | (1.15, 1.36) | 1.13 | (1.04, 1.24) |
| Overweight and obesity | 170 | 59 | 1.39 | (1.03, 1.88) | 143 | 55 | 1.55 | (1.13, 2.11) | 139 | 53 | 1.53 | (1.12, 2.11) | 1.43 | (1.04, 1.96) |
| Cholelithiasis or disorders of the gallbladder | 717 | 203 | 1.14 | (0.97, 1.34) | 623 | 176 | 1.14 | (0.96, 1.35) | 607 | 165 | 1.09 | (0.92, 1.30) | 1.05 | (0.88, 1.25) |
| Benign neoplasm of ovary | 324 | 105 | 1.31 | (1.05, 1.64) | 269 | 88 | 1.32 | (1.03, 1.69) | 263 | 81 | 1.24 | (0.96, 1.60) | 1.21 | (0.95, 1.56) |
| Ovarian dysfunction | 204 | 58 | 1.14 | (0.85, 1.53) | 178 | 55 | 1.24 | (0.91, 1.68) | 178 | 53 | 1.19 | (0.88, 1.63) | 1.17 | (0.86, 1.59) |
| Noninflammatory disorders of ovary, fallopian tube, and broad ligament | 260 | 73 | 1.13 | (0.87, 1.47) | 238 | 66 | 1.11 | (0.84, 1.46) | 233 | 63 | 1.08 | (0.82, 1.44) | 1.05 | (0.79, 1.39) |
| Disorders of thyroid gland | 1,449 | 431 | 1.21 | (1.08, 1.35) | 1,298 | 379 | 1.18 | (1.05, 1.33) | 1,263 | 360 | 1.15 | (1.02, 1.30) | 1.11 | (0.98, 1.25) |
| Endometriosis | 370 | 137 | 1.51 | (1.24, 1.85) | 303 | 111 | 1.49 | (1.19, 1.86) | 297 | 108 | 1.48 | (1.18, 1.85) | 1.44 | (1.15, 1.80) |
| Uterine leiomyoma | 903 | 311 | 1.42 | (1.24, 1.63) | 758 | 242 | 1.30 | (1.12, 1.52) | 743 | 236 | 1.30 | (1.11, 1.51) | 1.20 | (1.03, 1.40) |
| Disorders of parathyroid gland | 35 | 14 | 1.60 | (0.86, 2.98) | 30 | 9 | 1.20 | (0.57, 2.53) | 29 | 9 | 1.24 | (0.59, 2.62) | 1.14 | (0.54, 2.43) |
| Benign neoplasma of rectum and anal canal | 37 | 6 | 0.65 | (0.27, 1.54) | 32 | 5 | 0.63 | (0.24, 1.61) | 32 | 3 | 0.38 | (0.12, 1.23) | 0.62 | (0.24, 1.61) |