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. 2015 Nov 25;10(11):e0143979. doi: 10.1371/journal.pone.0143979

Fig 5. Histological analysis of kidneys in LETO and OLETF rats.

Fig 5

(A) Representative histological images are shown of glomerular, tubular and tubulointerstitial lesions of each group 12 weeks after the start of Paigen diet feeding. Scale bar, 100 μm. Glomerular volume (B), glomerular sclerosis index (C) and macrophage (CD68)-positive cells in glomeruli (D) are presented as mean ± SD. There were five animals in the group of LETO rats fed normal chow (LETO-NC), eight in the group of OLETF rats fed normal chow (OLETF-NC), and 11 in the group of OLETF rats fed a Paigen diet (OLETF-PD). #p < 0.05; ##p < 0.01; NS, not significant by unpaired t-test. ORO, Oil red O stain; PAS, periodic acid schiff stain.