Fig 5. The Mice Transplanted with Bone Marrow Cells Transduced with MYC-deleted Retroviral cDNA Library Developed Acute Myeloid Leukemia Harboring MEIS1 and One of Four HOX cDNA Inserts.

The leukemic cells from the 8 mice that have developed leukemia were analyzed in terms of their surface phenotype and cDNA inserts. The bone marrow cells were transduced with the retroviral cDNA library supernatant on Day 1 and again on Day 2. One million retrovirus-transduced bone marrow cells were transplanted into 9 irradiated host mice. One mouse died at Day 7 with unknown cause and was excluded from the analysis. A. Mouse 2–3 (MEIS1 + HOXA6), B. Mouse 2–10 (MEIS1 + HOXB6), C. Mouse 2–9 (MEIS1 + HOXB7). D. Mouse 2–6 (MEIS1 + HOXD8).