Fig. 3.

Time course of relative Aβ₄₀ in sNEP-treated C57BL/6J eyes. Each data point represents results from ≥ 3 animals. The inset shows results obtained with post-treatment periods of 30 min, and 2, 4, 8 and 24 hr. For clarity, the main figure omits the data at 2, 4 and 8 hr. With 30 min and 2 hr post-treatment periods, relative Aβ did not differ significantly from unity (p>0.05). However, at 24 hr, relative Aβ₄₀ was decreased to 0.22 ± 0.14, and a low level (~0.2–0.3) was maintained with post-treatment periods up to 8 weeks. Relative Aβ determined at 12 weeks post-treatment (0.51 ± 0.18), while less than unity (p < 0.001), significantly exceeded that exhibited at 8 weeks (0.25 ± 0.11; p = 0.01).