Table 2. Single Nucleotide Polymorphisms (SNPs) in fibronectin binding protein A (fnbA) in the derivation cohort, external validation cohort, and late S. aureus bacteremia (SAB) group.
In the derivation cohort, no SNPs occurred with greater frequency in the prosthetic joint infection group (PJI) relative to the uninfected prosthetic joint group (PJU). In the external validation cohort, one SNP (S839N) was significantly associated with the PJU group, though when the two cohorts were combined the S839N association did not reach statistical significance (p = 0.22). Late SAB was defined as bacteremia occurring >1 year after placement or manipulation of prostheses, and here contains data from both the derivation and external validation cohorts. In the late SAB group, no SNPs occurred with greater frequency in PJI or PJU.
| NONSYNONYMOUS SNP | DERIVATION COHORT | EXTERNAL VALIDATION COHORT | LATE S. AUREUS BACTEREMIA | ||||||
|---|---|---|---|---|---|---|---|---|---|
| PJI (n = 27) | PJU (n = 43) | P-value | PJI (n = 12) | PJU (n = 58) | P-value | PJI (n = 27) | PJU (n = 80) | P-value | |
| REPEAT 1 | |||||||||
| T539K | 1 | 0 | 0.39 | 0 | 2 | 1.00 | 1 | 0 | 0.25 |
| REPEAT 2 | |||||||||
| G563E | 3 | 6 | 1.00 | 1 | 11 | 0.68 | 4 | 17 | 0.58 |
| REPEAT 5 | |||||||||
| E652D | 2 | 5 | 0.70 | 0 | 10 | 0.19 | 4 | 15 | 0.78 |
| V668I | 2 | 0 | 0.15 | - | - | 1 | 0 | 0.25 | |
| REPEAT 6 | |||||||||
| S678I | 1 | 0 | 0.15 | 0 | 2 | 1.00 | 0 | 0 | 1.00 |
| V698I | 4 | 8 | 0.76 | 0 | 14 | 0.11 | 4 | 20 | 0.42 |
| K703E | 27 | 40 | 0.28 | 2 | 24 | 0.19 | 16 | 47 | 1.00 |
| REPEAT 7 | |||||||||
| D723G | 4 | 7 | 1.00 | 0 | 15 | 0.06 | 4 | 19 | 0.42 |
| REPEAT 8 | |||||||||
| G741S | - | - | - | 1 | 0 | 0.17 | 1 | 0 | 0.25 |
| N750D | 1 | 0 | 0.39 | 0 | 2 | 1.00 | 0 | 0 | 1.00 |
| REPEAT 9 | |||||||||
| P779T | - | - | - | 0 | 7 | 0.34 | 0 | 1 | 1.00 |
| H782Q | 1 | 0 | 0.39 | 0 | 2 | 1.00 | 0 | 2 | 1.00 |
| K786N | 3 | 6 | 0.39 | 0 | 13 | 0.11 | 1 | 13 | 0.11 |
| N788D | - | - | - | 0 | 2 | 1.00 | 0 | 2 | 1.00 |
| K797E | - | - | - | 0 | 3 | 1.00 | 0 | 2 | 1.00 |
| REPEAT 10 | |||||||||
| H804Q | 2 | 2 | 0.64 | 0 | 2 | 1.00 | 1 | 2 | 1.00 |
| H818Q | 1 | 0 | 0.39 | 0 | 2 | 1.00 | 0 | 0 | 1.00 |
| T826N | 2 | 0 | 0.15 | 0 | 3 | 1.00 | 1 | 0 | 0.25 |
| REPEAT 11 | |||||||||
| S839N | 6 | 10 | 1.00 | 0 | 20 | 0.01* | 5 | 25 | 0.23 |
| N846S | - | - | - | 0 | 2 | 1.00 | 0 | 1 | 1.00 |
| S847I | - | - | - | 0 | 1 | 1.00 | 0 | 1 | 1.00 |
| K857H/Q | 0 | 1 | 1.00 | 0 | 2 | 1.00 | 0 | 2 | 1.00 |
| Q861H | 0 | 1 | 1.00 | 0 | 2 | 1.00 | 0 | 2 | 1.00 |
*When false discovery rate control is applied, this raw p-value no longer maintains statistical significance (p = 0.22).