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. 2015 Nov 25;10(11):e0143742. doi: 10.1371/journal.pone.0143742

Fig 1. Representation of differentially expressed and alternatively spliced genes after berberine treatment.

Fig 1

A. The expression or alternative splicing of DPM1 gene remained unchanged after berberine treatment. B. The splicing pattern of NFKBIA gene remained unchanged after berberine treatment as indicated by the splicing index (SI) value of each of its exons. However, the expression of NFKBIA gene was upregulated by more that 2-fold after berberine treatment (p<0.05) since each of its exons were overexpressed. C. The splicing pattern of RLIM gene was altered by berberine treatment as indicated by the SI value of exon 2 (SI < 0.5) within RLIM gene. But the expression of RLIM gene did not changed significantly after berberine treatment. Relative expression, the relative expression level of the gene or all its exons compared to the control sample. *, DEG; #, DSAG.