FIG. 1.

Effects of anti-tumor necrosis factor (TNF)α antibody on nitrogen mustard (NM)-induced structural changes in the lung. Sections, prepared 3, 7, and 28 days after exposure of rats to NM or PBS control (CTL), followed by anti-TNFα antibody or PBS, were stained with H&E. Panel A, original magnification, ×4; Panel B, original magnification, ×200. Arrows, bronchial epithelium hypertrophy and hyperplasia; b, bronchiolization of alveolar septal wall; f, fibrin deposits; e, perivascular edema; em, emphysema; fib, fibrosis. Representative sections from 1 of 3–7 rats/treatment group are shown. CTL, 3 days post PBS exposure.