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. Author manuscript; available in PMC: 2016 Apr 8.
Published in final edited form as: Nature. 2015 Sep 7;526(7572):224–229. doi: 10.1038/nature14853

Figure 1. Receptor architecture.

Figure 1

a–c, The 3D reconstruction maps, viewed parallel to the membrane (str-bound in blue, gly-bound in yellow and gly/ivm-bound in red). One subunit is highlighted. The densities for strychnine and ivermectin are orange and green, respectively. d–f, Cartoon representations of the corresponding models of reconstructions shown in a–c, viewed in parallel to the membrane plane. The Asn-linked carbohydrate and associated Asn54 residue are in stick representation. g–i, Views of the structures from the extracellular side of the membrane. Residues −2′Pro (Pro266) and 9′Leu (Leu277) reside on the pore-lining M2 helix.