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. Author manuscript; available in PMC: 2016 Apr 8.
Published in final edited form as: Nature. 2015 Sep 7;526(7572):224–229. doi: 10.1038/nature14853

Figure 2. The ion channel.

Figure 2

a–c, Two sites of pore constriction are at −2′Pro and 9′Leu, viewed from the cytoplasmic side, with their Cα in cyan and magenta spheres, respectively. Distances are in Ångstrom. d, Plot of the pore-lining M2 as represented by the vector connecting −2′ProCα and 9′LeuCα, with −2ProCα as the origin, the tilt angle θ and the rotation angle φ relative to the pore axis. The φ of str-bound GlyR is set to zero. e–g, Sagittal ‘slice’ views along the pore axis. h–j, Shape and size of the ion permeation pathway. M2 of two subunits are shown as ribbon representation, where the side chains of the pore-lining residues are shown in sticks. Blue, green and red spheres define radii of >3.3Å, 1.8–3.3 Å and <1.8 Å, respectively. k, Plot of pore radii as a function of distance along the pore axis. The Cα position of 0′Arg is set to zero.