Figure 1. Effect of a single injection of amphetamine on BDNF protein expression.

Male Sprague Dawley rats were given an i.p. injection of amphetamine 2 mg/kg. Animals were killed 24 h after drug treatment and BDNF levels in dissected striatal, hippocampal and prefrontal cortical tissues were measured by ELISA method. BDNF levels were computed as percentages relative to basal BDNF levels. Each bar is the mean ± SEM (n=6–9 animals). **p<0.01, compared to the control group.