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Two critical phosphorylation sites of Akt has different downstream targets in certain disease conditions. For example Phosphorylation of Akt at T308 significantly increases phosphorylation of PRAS40, TBC1D4 and TSC2 where Phosphorylation of S473 has less effect on these substrates. In similar manner, phosphorylation of S473 significantly increases phosphorylation of BAD. However GSK3 can be phosphorylated by any of the critical phosphorylations on Akt1.
