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Second generation purine analogs with enhanced potency and solubility. IC50a values for 69-71 correspond to anti-proliferative activity in MCF-7 cells (MTS assay) and SkBr3 cells (sulforhodamine B assay) for 72. IC50b corresponds to the Her2 degradation assay 69-72 in the same cell lines used for determining anti-proliferative activity. 73-74 represent rationally designed purine analogs. 75 is a purine-based Grp94-selective inhibitor
