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Natural product resorcinol-based inhibitors of Hsp90 (4, 44-46). 47-49 synthetic analogs of 4 to increase in vivo stability. ICa50 represents IC50 values of antiproliferative activity against the MCF-7 breast cancer (4, 44, 47-48) and the KNRK5.2 (49) cell line. ICb50 represents IC50 values of a time-resolved fluorescence resonance energy transfer (TR-FRET) assay.
