Table I.

The six hallmarks of cancer and Hsp90-dependent client proteins associated with each hallmark.

Hallmarks of Cancer	Hsp90 Client Protein(s)
1) Self-sufficient growth signals	Raf-1, AKT, Her2, MEK, Bcr-Abl
2) Insensitive to anti-growth signals	Plk, Wee1, Myt1, CDK4, CDK6
3) Evasion of apoptosis	RIP, AKT, mutant p53,c-MET, Apaf-1, Survivin
4) Limitless replicative potential	Telomerase (h-Tert)
5) Sustained angiogenesis	FAK, AKT,Hif-1α, VEGFR, Flt-3
6) Tissue invasion and metastasis	C-MET