Table 5.

Risk of sudden cardiac death with domperidone exposure: case-crossover analysis, results of individual conditional logistic regression models for each of the three study exposures

	N	Number of control windows exposed				ORa	95 % CI
		3	2	1	0
Total cases in each modelb	2271
Domperidone usec						3.17	1.72–5.83
Cases with three control windows	1154
Case window exposed	34	8	10	3	13
Case window unexposed	1120	3	0	6	1111
Cases with two control windows	661
Case window exposed	12		6	2	4
Case window unexposed	649		1	5	643
Cases with one control window	456
Case window exposed	12			6	6
Case window unexposed	444			2	442
PPI usec						1.02	0.87–1.19
Cases with three control windows	1154
Case window exposed	625	412	115	57	41
Case window unexposed	529	48	72	73	336
Cases with two control windows	661
Case window exposed	384		266	86	32
Case window unexposed	277		40	56	181
Cases with one control window	456
Case window exposed	282			230	52
Case window unexposed	174			51	123
Metoclopramide usec						3.08	1.67–5.66
Cases with three control windows	1154
Case window exposed	20	7	4	0	9
Case window unexposed	1134	0	2	7	1125
Cases with two control windows	661
Case window exposed	13		3	4	6
Case window unexposed	648		1	5	642
Cases with one control window	456
Case window exposed	20			9	11
Case window unexposed	436			2	434

OR odds ratio, CI confidence interval, PPI proton pump inhibitor

^aFrom conditional logistic regression on the matched sets. Separate models were constructed for each of the three study exposures

^bOf the 3282 cases of sudden cardiac death in the study, 2271 had at least one control window identified and were included in the case-crossover analysis

^cWith or without use of another study medication