Table 2.
Summary of the Absolute Levels: Treatment Group Comparison of Lipids Over Time
| Metabolic Parameters | Study Week | ATV/r | RAL | DRV/r |
|---|---|---|---|---|
| Mean (95% CI) | Mean (95% CI) | Mean (95% CI) | ||
| Fasting total cholesterol, mg/dL | 0 | 156.7 (154.0–159.4) | 158.3 (155.4–161.2) | 157.0 (154.0–160.0) |
| 24 | 166.3 (163.1–169.4) | 157.9 (154.9–160.9) | 169.2 (166.1–172.3) | |
| 48 | 169.8 (166.4–173.2) | 159.5 (156.5–162.4) | 172.3 (168.9–175.6) | |
| 96 | 172.3 (169.0–175.6) | 163.4 (160.3–166.4) | 172.4 (169.0–175.8) | |
| Fasting HDL-C, mg/dL | 0 | 38.8 (37.8–39.8) | 39.5 (38.3–40.6) | 40.4 (39.2–41.5) |
| 24 | 43.4 (42.2–44.6) | 43.9 (42.7–45.0) | 44.4 (43.1–45.7) | |
| 48 | 45.1 (43.8–46.5) | 44.5 (43.3–45.7) | 45.9 (44.6–47.1) | |
| 96 | 45.2 (43.9–46.5) | 45.4 (44.2–46.7) | 45.6 (44.2–47.0) | |
| Fasting triglycerides, mg/dL | 0 | 123.8 (117.2–130.4) | 123.4 (116.9–129.9) | 124.3 (117.1–131.5) |
| 24 | 140.3 (133.0–147.6) | 109.3 (103.4–115.2) | 137.3 (129.7–144.9) | |
| 48 | 139.7 (132.1–147.4) | 115.3 (108.8–121.9) | 139.5 (131.3–147.6) | |
| 96 | 140.9 (133.0–148.8) | 116.3 (109.6–122.9) | 141.1 (131.1–151.1) | |
| Fasting non–HDL-C, mg/dL | 0 | 117.9 (115.4–120.4) | 118.8 (116.2–121.5) | 116.6 (113.9–119.3) |
| 24 | 122.9 (119.9–126.0) | 114.0 (111.1–116.9) | 124.8 (121.8–127.9) | |
| 48 | 124.6 (121.4–127.9) | 115.0 (112.1–117.8) | 126.5 (123.2–129.7) | |
| 96 | 127.1 (123.9–130.3) | 118.0 (114.9–121.0) | 126.9 (123.6–130.1) | |
| Fasting calculated LDL, mg/dL | 0 | 93.7 (91.4–96.0) | 94.9 (92.4–97.5) | 93.0 (90.5–95.4) |
| 24 | 95.4 (92.8–98.1) | 92.2 (89.7–94.7) | 98.0 (95.3–100.6) | |
| 48 | 97.4 (94.5–100.2) | 92.0 (89.6–94.3) | 99.1 (96.3–101.9) | |
| 96 | 99.4 (96.5–102.3) | 95.1 (92.5–97.7) | 99.9 (97.1–102.7) | |
| Fasting plasma glucose, mg/dL | 0 | 88.0 (86.2–89.8) | 87.4 (85.6–89.2) | 85.6 (84.0–87.1) |
| 24 | 90.3 (88.1–92.5) | 89.2 (87.4–91.0) | 88.9 (87.0–90.9) | |
| 48 | 89.5 (87.9–91.2) | 89.0 (86.8–91.3) | 87.0 (85.6–88.5) | |
| 96 | 90.2 (88.3–92.2) | 88.6 (87.0–90.3) | 88.9 (86.9–90.9) | |
| Waist:height ratio, cm:cm | 0 | 0.53 (.52–.53) | 0.53 (.52–.53) | 0.52 (.51–.53) |
| 24 | 0.54 (.53–.54) | 0.54 (.53–.54) | 0.53 (.52–.53) | |
| 48 | 0.54 (.53–.55) | 0.54 (.54–.55) | 0.53 (.52–.54) | |
| 96 | 0.55 (.54–.55) | 0.55 (.54–.56) | 0.53 (.52–.54) |
Abbreviations: ATV/r, ritonavir-boosted atazanavir; CI, confidence interval; DRV/r, ritonavir-boosted darunavir; HDL-C, high-density lipoprotein cholesterol; LDL, low-density liproprotein cholesterol; RAL, raltegravir.