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. 2015 Mar 2;34(46):5699–5708. doi: 10.1038/onc.2015.24

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Copyright © 2015 Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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SETD2 mutation exposes H3K36me3 sites to chromosome breakage. (a) Schematic illustrating the mapping of chromosomal breakpoint regions to sites of H3K36me3/H3K27me3 (data from the ENCODE consortium) in both SETD2_LOH and SETD2_mut. Breakpoint regions, identified from SNP 6.0 array data, are the regions between two segments of a chromosome present at different allele-specific copy numbers. (b) Representative plots of observed H3K36me3 frequencies against expected frequencies in SETD2_LOH and SETD2_mut tumours, using a minimum segment length of 10 Mb and a maximum breakpoint region length of 20 kb.